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KMID : 1123920140280060601
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Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 6 p.601 ~ p.606
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Effects of Acupuncture at the Wijung(BL40) and Chok-Samni(ST 36) on the Cerebral Blood Flow and Blood Pressure
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Jung Hyun-Woo
Kim Jin-Woo
Han Yang-Shin
Choi Chan-Hun
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Abstract
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The purpose of this study is to research the effects of acupuncturing BL40 and ST36 and to determine the
mechanism of action of acupuncturing BL40 and ST36 by measuring the changes of regional cerebral blood flow
(rCBF) and mean arterial blood pressure (MABP) in normal rats. To determine the mechanism of action of
acupuncturing BL40 and ST36, pretreatment with indomethacine and methylene blue was performed. Acupuncturing
BL40 and ST36 significantly increased rCBF, and the increased rCBF by acupuncturing BL40 and ST36 was
significantly inhibited by pretreatment with indomethacin (1 ㎎/㎏, i.p.), an inhibitor of cyclooxygenase, and methylene
blue(10 ㎍/㎏, i.p.), an inhibitor of guanylate cyclase. Acupuncturing BL40 and ST36 decreased MABP, and decreased
MABP by acupuncturing BL40 and ST36 was not changed by pretreatment with indomethacin and methylene blue. This
result suggested that acupuncturing BL40 and ST36 might significantly increase rCBF by dilating arterial diameter and
mechanism of acupuncturing BL40 and ST36 might be mediated by cyclooxygenase and guanylate cyclase.
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KEYWORD
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Wijung(BL40), Chok-Samni(ST36), regional cerebral blood flow (rCBF), mean arterial blood pressure (MABP)
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